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KMID : 1159320220240010033
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Korean Journal of Vision Science
2022 Volume.24 No. 1 p.33 ~ p.42
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Effect of Antiplatelet Drugs on the Development of Vitreous Hemorrhage in Patients with Atrial Fibrillation
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Choy Yoon-Jung
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Abstract
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Purpose : This study aimed to investigate the incidence and risk factors of vitreous hemorrhage in patients with atrial fibrillation (AF) using thrombolytic agents with long-term follow-up.
Methods : Patients diagnosed with AF between 2002 and 2006 were selected from the National Health Insurance Corporation database and followed-up from 2007 to 2013. To investigate the relationship between the use of antiplatelets (aspirin and cilostazol) and vitreous hemorrhage, patients were divided based on length of antiplatelet use (<1 year, 1~4 years, and ≥4 years).
Results : A total of 7,471 patients were enrolled. Ninety-eight patients developed vitreous hemorrhage, of which 25 patients were taking aspirin (<1 year: 9[36%] patients, 1~4 years: 9[36%] patients, and ≥4 years: 7[28%] patients). The hazard ratio for developing vitreous hemorrhage after taking aspirin for 1~4 years was 0.799 and for ≥4 years was 0.489. In addition, 13 patients who developed vitreous hemorrhage were taking cilostazol (<1 year: 7[53.8%] patients, 1~4 years: 4[30.8%] patients, and ≥4 years: 2[15.4%] patients). The hazard ratios for developing vitreous hemorrhage after taking cilostazol for 1~4 years and for ≥4 years were 0.757 and 1.202, respectively. The cumulative incidence of vitreous hemorrhage at 12-years follow-up was 4.6%.
Conclusion : Long-term follow-up of patients with AF revealed that the use of aspirin and cilostazol may increase the risk of vitreous hemorrhage. However, vitreous hemorrhage was found to be multifactorial because the frequency of diabetic mellitus and hypertension was high in patients with vitreous hemorrhage.
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KEYWORD
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Aspirin, Atrial fibrillation, Cilostazol, Vitreous hemorrhage
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